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Our research is focused on understanding how the function of pathogen-specific B cells and T cells are regulated during infectious disease. Our broader goals are to use this information to identify and develop new strategies to improve immunity against globally important diseases like malaria and other microbial infections.
To achieve our goals, we are performing experiments designed to elucidate the molecular and transcriptional mechanisms that determine how infection, inflammation and immunotherapy regulate the formation of long-lived, pathogen-specific memory T cell and B cell subsets.
As part of our efforts, we also perform comprehensive, comparative studies using models of vaccination, bacterial and viral infection, and we investigate host immunity using related eukaryotic pathogens.